王恒山 [教授]

----个人基本信息----

---教育和主要工作经历---

   2000年毕业于兰州大学，获理学博士学位， 2004任广西师范大学化学化工学院教授， 2006年11月赴美国杰克逊州立大学访问, 获广西“特聘专家”、广西“新世纪十百千人才工程”第二层次人选，广西师范大学省部共建“药用资源化学与药物分子工程”国家重点实验室和广西民族药省部共建协同创新中心副主任/秘书长。

         先后主持973前期研究专项1项、国家自然科学基金项目5项、国际合作项目1项、国家科技支撑计划项目子课题1项，以及高等学校博士学科点专项基金、广西重点研发计划和重点项目等其他省部级、厅级课题14项；以第三成员参加国家自然科学基金重点项目1项、973前期研究专项1项。共在Org. Lett., Sci. Chi. Chem., Green Chem., J. Med. Chem., Eur. J. Med. Chem., Chem. Commun., Phytochemistry, Phytomedicine, Bioconjugate Chem., Adv. Synth. Catal., Bioorg. Med. Chem., Food Chemistry, Food Res. Int., LWT - Food Sci. Technol. 化学和药学类期刊发表论文300余篇，其中200余篇被SCI收录（含JCR一、二区论文80余篇）。研究成果在Chem. Rev., Chem. Soc. Rev. J. Am. Chem. Soc., ACS Catalysis, Green Chem.等刊物被他人正面引用2000余次，单篇最高引用频次200次。参编英文专著1部。获得广西自然科学奖二等奖2项（排名第一、六）、广西科技进步二等奖4项（排名第二、二、三、五）、广西自然科学三等奖1项（排名第一）和广西科技进步三等奖（排名第五）各1项。获8项国家发明专利授权，部分新产品已被美国Sigma-Aldrich等公司采用。在国际和全国学术会议做邀请报告5次。已培养博士7名、硕士70名。

         中国化学会员、中国化工学会专家库专家，广西化学化工学会专家库专家，广西化学化工学会理事，河北省杂环化合物重点实验室学术委员会副主任。韶关市企业创新发展专家库专家，《广西植物》、《广西师范大学学报》编委和Chem. Sci., J. Med. Chem., J. Nat. Prod., Adv. Synth. Catal., J. Org..Chem., Eur. J. Med.Chem., Phytomed., Phytochem., J. Med. Food., Pharm. Bio., New J. Chem., Molecular Nutrition & Food Research等20余种SCI刊物的特约审稿人。

---讲授的课程---

天然药物化学、波谱解析、天然产物开发与利用、中药鉴定及质量控制、表征技术

---研究领域--- 

主要研究和感兴趣的领域：

中药与天然药物化学、手性药物的结构改造与分离分析研究，功能分子的合成方法学。

---近年研究项目--- 

1 .973计划前期研究专项(No.2011CB512005)：基于广西主产中药活性成分的手性氨基膦酸酯基抗肿瘤和抗病毒药物的前期研究。

2. 国家自然科学基金(No. 21977021):源于紫堇属瑶药的非温敏型生物碱类TRPV1调节剂的发现与结构优化及特异机制研究

3. 国家自然科学基金(No. 81760626): 卷柏属瑶药中新型PDE4 / MMPs双靶点抑制剂的协同抗肿瘤耐药机制。

4. 国家自然科学基金(No. 81260472): 天然萜烷和氨基酸背景(环)磷酰胺衍生物的手性与肿瘤细胞抑制作用相互关系。

5. 广西重点研发计划（No.2017AB44061）: 基于样品库中新型肿瘤和病毒靶点抑制剂筛查的十种瑶药标准制定

6. 高等学校博士学科点专项科研基金博导类资助课题（No.20134504110002）: 三类天然骨架含氮磷小分子抗肿瘤药物的串联反应合成与活性研究。

7. 国家自然科学基金重点项目（No.21431001）: 基于中药活性成分的金属抗肿瘤配合物研究(第三成员)

---企业研发项目---

1. 三金片浸膏主要化学成分分离鉴定及含量测定用化学对照品纯化制备研究

2. 壮药羊开口主要化学成分分离鉴定和含量测定用化学对照品纯化制备研究

3. 丹参酮系列中药注射剂的中药现代化研究

4. 海南椰油主成分鉴定及含测研究

---科研奖励--- 

1. 王恒山、潘英明、梁英、陈振锋、张业、徐艳丽，若干绿色催化体系在五元氮杂环药物骨架构筑及手性氮碳磷键侧链修饰中的应用，广西科技进步奖二等奖，2016年

2.王恒山、潘英明、赵书林、梁英、王凯、何春欢，特色桂药抑制活性氧自由基损伤功效物质基础及作用机制的研究与应用，广西自然科学奖三等奖，2012年

3.梁东、王恒山、覃仁俊、陈力键、石伟、樊 化、潘其明、毛丹翎、刘涛乾、张 斌. 山豆根等壮瑶药的活性成分与质控技术及应用，广西科学技术进步奖二等奖，2023年

4.潘英明、王恒山、吴强、黄宇平、杨韶平、张业、王迎春、陈键泉、黄晓超. 松香手性产品深加工技术及其生产工艺的研发与应用，广西科技进步奖二等奖，2015年

5.方显明、谢金鲜、覃振林、方兴、王恒山、唐友明、兰树彬、欧阳熙林、韦斌，广西特色壮药经血宁胶囊的研发与临床应用，广西科技进步奖二等奖，2014年

6.赵书林、叶芳贵、卢　昕、田建袅、李舒婷、王恒山，微流控芯片和毛细管电泳新方法及其在单细胞和体液分析中的应用研究，广西自然科学奖二等奖，2010年

7.赵书林、李舒婷、王恒山等，毛细管电泳新技术及其在生物和药物分析中的应用研究，广西科技进步奖二等奖，2007年

8. 张业、义祥辉、覃雯、潘英明、王恒山、程忠泉、陈力健，基于白藜芦醇骨架改造的化合物的制备及其抗氧化、抗肿瘤活性研究，广西科技进步奖三等奖，2014年

9. 邱建华、沈星灿、梁宏、赵书林、梁毅、王恒山等《高师院校化学一流专业“一核心两主线三保障四途径”人才培养体系构建与实践》，广西壮族自治区教学成果一等奖，2021年。

---代表性成果--- 

合成药物化学方向

1. Meng Wang, Guoxiu Cao, Junjie Zhou, Jinyuan Cai, Xianjie Ma, Zhikun Liu*, Xiaochao Huang*, Hengshan Wang*. Ligustrazine-Derived Chalcones-Modified Platinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancer through Ferroptosis and Apoptosis. J. Med. Chem., 2023, 66(19): 13587-13606.

2. Liu Zhikun, Wang Meng, Huang Rizhen, Hu Tianhui, Jing Yi, Huang Xiaochao, Hu Weiwei, Cao Guoxiu*, Wang Hengshan*. Novel Indole-Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate Cisplatin Resistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction. J. Med. Chem., 2023, 66(7): 4868-4887.

3. Rizhen Huang, Xiaoteng Jing, Xiaochao Huang, Yingming Pan, Yilin Fang, Guibin Liang, Zhixin Liao, Hengshan Wang*, Zhenfeng Chen*, and Ye Zhang*. Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-Dioxygenase and Signal Transducer and Activator of Transcription 3. J. Med. Chem., 2020, 63(4): 1544-1563.

4. Xiang-Jun Peng, Hai-Ping He , Qian Liu , Kun She , Bao-Qi Zhang , Heng-Shan Wang*, Hai-Tao Tang*, Ying-Ming Pan*. Photocatalyst-controlled and visible light-enabled selective oxidation of pyridinium salts. Scie. China Chem., 2021, 64(5): 1-8.

5. Xiaochao Huang, Yuanhang Chen, Wentian Zhong, Zhikun Liu*, Haijiang Zhang, Bin Zhang*, Hengshan Wang*. Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment. Eur. J Med. Chem., 2022, 244: 114817.

6. Xiaochao Huang*, Meng Wang, Qinghong You, Jing Kong, Haijiang Zhang, Chunhao Yu, Yanming Wang, Hengshan Wang*, Rizhen Huang*. Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents. Eur. J. Med. Chem., 2020, 189, 112067.

7. Xiao-Chao Huang, Xiaochao Huang, Rizhen Huang, Zhimei Wang, Lingxue Li, Shaohua Gou*, Zhixin Liao, Heng-Shan Wang*. Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells. Eur. J. Med. Chem., 2018, 146, 435-450.

8. Xiaochao Huang, Shixian Hua, Rizhen Huang, Zhikun Liu, Shaohua Gou*, Zhimei Wang, Zhixin Liao, Hengshan Wang*. Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues. Eur. J. Med. Chem., 2018, 148, 1-25.

9. Ri-Zhen Huang, Gui-Bin Liang, Xiao-Chao Huang, Bin Zhang, Mei-Mei Zhou, Zhi-Xin Liao*, Heng-Shan Wang*. Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. Eur. J. Med. Chem., 2017, 138, 979-992.

10. Xiaochao Huang, Rizhen Huang, Lingxue Li, Shaohua Gou, Hengshan Wang*. Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. Eur. J. Med. Chem., 2017, 132, 11-25.

11. Jian-Mei Qin, Ri-Zheng Huang, Xiao-Chao Huang, Gui-Yang Yao, Ying-Ming Pan* and Heng-Shan Wang*. Terminal functionalized thiourea-containing dipeptides as multidrug- resistance reversers that target 20S proteasome and cell proliferation. Eur. J. Med. Chem., 2017, 126, 259-269.

12. Man-Yi Ye, Gui-Yang Yao, Ying-Ming Pan, Zhi-Xin Liao, Ye Zhang, Heng-Shan Wang*. Synthesis and antitumor activities of novel α-aminophosphonate derivatives containing an alizarin moiety. Eur. J. Med. Chem., 2014, 83, 116–128.

13. Jian-Fei Li, Ri-Zhen Huang, Gui-Yang Yao, Man-Yi Ye, Heng-Shan Wang*, Ying-Ming Pan*, Jing-Teng Xiao. Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents. Eur. J. Med. Chem., 2014, 86, 175–188. 

14. Hong-En Qu , Ri-Zhen Huang, Gui-Yang Yao, Jiu-Ling Li, Man-Yi Ye, Heng-Shan Wang*, Liangxian Liu*. Synthesis and pharmacological evaluation of novel bisindole derivatives bearing oximes moiety: Identification of novel proapoptotic agents, Eur. J. Med. Chem., 2015, 95, 400−415.

15. Xiao-Chao Huang, Le Jin, Meng Wang, Dong Liang, Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan, Heng-Shan Wang*. Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. Eur. J. Med. Chem., 2015, 89, 370−385.

16. Shi-Xian Hua, Ri-Zheng Huang, Man-Yi Ye, Ying-Ming Pan, Gui-Yang Yao, Ye Zhang*, Heng-Shan Wang*, Design, synthesis and in vitro evaluation of novel ursolic acid derivatives as potential anticancer agents. Eur. J. Med. Chem., 2015, 95, 435−452.

17. Xiaochao Huang, Rizheng Huang, Zhixin Liao, Yingming Pan, Shaohua Gou*, Hengshan Wang*. Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. Eur. J. Med. Chem., 2016, 108, (27), 381-391.

18. Xiao-Chao Huang, Meng Wang, Ying-Ming Pan, Gui-Yang Yao, Heng-Shan Wang*, Xiao-Yan Tian, Jiang-Ke Qin, Ye Zhang. Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid. Eur. J. Med. Chem., 2013, 69, 508–520.

19. Lumei Dai , Feng Qin , Yuying Xie, Bin Zhang, Zhijie Zhang, Sijia Liang, Fujia Chen, Xiaochao Huang*, Hengshan Wang*. Antitumor activity and mechanisms of dual EGFR/DNA-targeting strategy for the treatment of lung cancer with EGFRL858R/T790M mutation. Bioorg. Chem., 2023, 135: 106510.

20. Meng Wang, Zhikun Liu, Xiaochao Huang, Yuanhang Chen, Yanming Wang, Jing Kong, Yong Yang, Chunhao Yu, Jin Li, Xu Wang*, Hengshan Wang*. Dual-target platinum(IV) complexes exhibit antiproliferative activity through DNA damage and induce ER-stress-mediated apoptosis in A549 cells. Bioorg. Chem., 2021, 110: 104741-104741.

21. Xiaochao Huang*, Meng Wang, Chungu Wang, Weiwei Hu, Qinghong You, Tianhua Ma, Qiang Jia, Chunhao Yu, Zhixin Liao*, Hengshan Wang*. Synthesis and biological evaluation of novel millepachine derivative containing aminophosphonate ester species as novel anti-tubulin agents. Bioorg. Chem., 2020, 94, 103486.

22. Le Jin, Lumei Dai,Min Ji*, Hengshan Wang*. Mitochondria-targeted triphenylphosphonium conjugated glycyrrhetinic acid derivatives as potent anticancer drugs. Bioorg. Chem., 2019, 85, 179-190.

23. Xiaochao Huang, Meng Wang, Chungu Wang, Weiwei Hu, Qinghong You, Yong Yang, Chunhao Yu, Zhixin Liao, Shaohua Gou*, Hengshan Wang*, Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 signifcantly exhibited potent ability to overcome cisplatin resistance. Bioorg. Chem., 2019, 92: 1032362.

24. Huang X, Liu Z, Wang M, Yin X, Wang Y, Dai L, Wang H*. Platinum(IV) complexes conjugated with chalcone analogs as dual targeting anticancer agents: In vitro and in vivo studies. Bioorg. Chem., 2020 , 105:104430.

25. Cai-Wen Fan, Mei-Shan Li, Xi-Xi Song, Li Luo, Jing-Chen Jiang, Jia-Zi Luo*, Heng-Shan Wang*. Discovery of novel 2-oximino-2-indolylacetamide derivatives as potent anticancer agents capable of inducing cell autophagy and ferroptosis. Bioorg. Med. Chem., 2023, 80: 117176.

26. Le Jin, Rizhen Huang, Xiaochao Huang, Bin Zhang, Min Ji* and Hengshan Wang*, Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90–Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance. Bioorgan. Med. Chem., 2018, 26, 1759–1775

27. Yu-Yang Xie, Ying-Chun Wang, Yan He, Da-Chao Hu, Heng-Shan Wang*, Ying-Ming Pan*. Catalyst-Free Synthesis of Fused 1, 2, 3-Triazole and Isoindoline Derivatives via Intramolecular Azide-Alkene Cascade Reaction. Green Chem., 2017, 19, 656–659.

28. Kun She, Feng Liang, Shichao Tian, Hengshan Wang*, Gavin Chit Tsui, Quande Wang*. Organocatalytic Three-omponent Acyldifluoromethylation of Vinylarenes via N-Heterocyclic Carbene-Catalyzed Radical Relay. Org. Lett., 2022, 24: 4840-4844.

29. Yong-Zhou Pan, Qiang Xia, Jin-Xiu Zhu, Ying-Chun Wang, Ying Liang, Hengshan Wang,* Hai-Tao Tang,* and Ying-Ming Pan*. Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO2 at Ambient Pressure. Org. Lett., 2022, 24, 8239−8243.

30. Yan He, Yingchun Wang, Xinping Liang, Bin Huang, Hengshan Wang*, and Ying-Ming Pan*. Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of NAcyl Propiolamides . Org. Lett., 2018, 20, 22, 7117-7120.

31. Xiao-Ying Huang, Rui Ding, Zu-Yu Mo, Yan-Li Xu, Hai-Tao Tang, Heng-Shan Wang*, Yan-Yan Chen, Ying-Ming Pan*. Photocatalytic Construction of S–S and C–S Bonds Promoted by Acridinium Salt: An Unexpected Pathway To Synthesize 1, 2, 4-Dithiazoles. Org. Lett., 2018, 20, 4819−4823.

32. Jiu-ling Li, Wei-ze Li, Ying-chun Wang, Qiu Ren, Heng-shan Wang,* and Ying-ming Pan*. Palladium(II)-Catalyzed C-C and C-O Bonds Formation for the Synthesis of C1-Benzoyl Isoquinolines from Isoquinoline N-Oxides and Nitro Alkenes. Chem. Commun., 2016, 52, 10028-10031.

33. Jiu-ling Li, Ying-chun Wang, Wei-ze Li, Heng-shan Wang*, Dong-liang Moa and Ying-ming Pan*. Facile synthesis of 2,5‐disubstituted oxazoles via a coppercatalyzed cascade reaction of alkenes with azides. Chem. Commun., 2015, 51, 17772-17774.

34. Bin Zhang, Xiaochao Huang, Hengshan Wang*, Shaohua Gou*. Promoting antitumor efficacy by suppressing hypoxia via nano self-assembly of two irinotecan-based dual drug conjugates having a HIF-1α inhibitor. J. Mater. Chem. B, 2019, 7(35): 5352-5362.

35. Xiaochao Huang, Rizhen Huang, Shaohua Gou, Zhimei Wang, Hengshan Wang*. Anticancer Platinum(IV) Prodrugs Containing Monoaminophosphonate Ester as a Targeting Group Inhibit Matrix Metalloproteinases and Reverse Multidrug Resistance. Bioconjugate Chem., 2017, 28 (4), 1305-1323.

36. Xiaochao Huang, Rizhen Huang, Shaohua Gou*, Zhimei Wang, Zhixin Liao, Hengshan Wang*. Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt (IV) Moiety with a Unique Mode of Action. Bioconjugate Chem., 2016, 27(9): 2132-2148. 

37. Yan He, Ying-Chun Wang, Kun Hu, Xiao-Ling Xu, Heng-Shan Wang*, Ying-Ming Pan*. Palladium-Catalyzed Synthesis of 5-Iminopyrrolones through Isocyanide Double Insertion Reaction with Terminal Alkynes and Water. J. Org. Chem., 2016, 81(23), 11813-11818.

38. Yan-li Xu, Ying-Ming Pan,* Qiang Wu, Heng-Shan Wang*, Pei-zhen Liu. Regioselective Synthesis of 1,3,5-Substituted Benzenes via the InCl3/2-iodophenol- Catalyzed Cyclotrimerization of Alkynes. J. Org. Chem. 2011, 76(20), 8472-08476.

39. Ying-Chun Wang, Yu-Yang Xie, Hong-En Qu, Heng-Shan Wang*, Ying-Ming Pan*, Fu-Ping Huang. Ce(OTf)3-catalyzed [3+2] cycloaddition of azides with nitroolefins: regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles. J. Org. Chem., 2014, 79, 4463−4469.

40. Jiu-ling Li, Da-chao Hu, Xin-ping Liang, Ying-Chun Wang, Heng-Shan Wang*, Ying-ming Pan*. Praseodymium (III)-Catalyzed Regioselective Synthesis of C3-N-substituted Coumarins with Coumarins and Azides. J. Org. Chem., 2017, 82, 9006−9011.

41. Xiu-Jin Meng, Ping-Fu Zhong, Yu-Mei Wang, Heng-Shan Wang*, Hai-Tao Tang*, Ying-Ming Pan*. Electrochemical Difunctionalization of Olefines: Access to Selenomethyl-Substituted Cyclic Ethers or Lactones. Adv. Synth. Catal., 2020, 362: 506-511.

42. Yingchun Wang, Jiuling Li, Yan He, Yuyang Xie, Hengshan Wang,* and Yingming Pan,* Synthesis of Polysubstituted Imidazoles and Pyridines via Samarium(III) Triflate-Catalyzed [2+2+1] and [4+2] Annulations of Unactivated Aromatic Alkenes with Azide. Adv. Synth. Catal., 2015, 357, 3229-3241.

43. Yu-Yang Xie, Ying-Chun Wang, Hong-En Qu, Xian-Chun Tan, Heng-Shan Wang*, Ying-Ming Pan*. Regioselective synthesis of β-Aryl enaminones and 1,4,5-trisubstituted 1,2,3-triazoles from chalcones and benzyl azides. Adv. Synth. Catal., 2014, 356, 3347–3355.

44. Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes. Org. Biomol. Chem., 2012, 10, 4696–4698.

45. Xu Wang, Ying-ming Pan*, Xiao-chao Huang, Zhong-yuan Mao and Heng-shan Wang*. A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents. Org. Biomol. Chem., 2014, 12, 2028-2032.

46. Xiaoguang Pan, Min Cao, Song Li, Hengshan Wang*, Xigong Liu*, and Lei Liu*. Synthesis of Diarylmethanes Bearing CF3- and CN-Substituted All-carbon Quaternary Centers and Diarylmalononitriles through Cyanation of δ-Disubstituted Para-Quinone Methides. Eur. J. Org. Chem., 2021, 1643-1646.

47. Wei-Gen Huang, Heng-Shan Wang*, Guo-Bo Huang, Yong-Ming Wu, Ying-Ming Pan*. Enantioselective friedel–crafts alkylation of n‐methylindoles with nitroalkenes catalyzed by chiral bifunctional abietic‐acid‐derived thiourea‐ZnII complexes. Eur. J. Org. Chem., 2012, 29, 5839–5843.

48. Gui-Yang Yao, Ya-Jun Li, Yong-Tao Zhu, Ying-Ming Pan, Fu-Ping Huang, Hengshan Wang*, Zhi-Xin Liao*. Protonation-controlled axial chirality in maleopimaric imides. New J. Chem., 2014, 38, 693–699.

49. Heng-Shan Wang*, Xiao-Yan Tian, Da Yang, Ying-Ming Pan, Qiang Wu, Chun-Huan He. Synthesis and enantiomeric recognition ability of 22-crown-6 ethers derived from rosin acid and BINOL. Tetrahedron: Asymmetry, 2011, 22(4), 381–386. 

50.  Qi Gao, Shen-Yan Li, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. The indium-catalysed hydration of alkynes using substoichiometric amounts of PTSA as additive. Tetrahedron, 2013, 69(19), 3775–3781.

51. Pei Liu, Ying-Ming Pan*, Kun Hu, Xiao-Chao Huang, Ying Liang, Heng-Shan Wang*. Ligand-free indium(III)-catalyzed Heck reaction. Tetrahedron, 2013, 69(37), 7925–7930.

52.  Ying-Chun Wang, Heng-Shan Wang*, Guo-Bao Huang, Fu-Ping Huang, Kun Hu, Ying-Ming Pan*. A one-pot approach to 4,5-dihydropyrazoles from ketones, arylacetylenes, and hydrazines. Tetrahedron, 2014, 70, 1621–1628. 

53.  Lu-Zhi Liu, Chun-Huan He, Lin Yang, Yan Huang, Qiang Wu, Wen-gui Duan, Heng-shan Wang*, Ying-ming Pan*. Novel C1-symmetric chiral crown ethers bearing rosin acids groups: synthesis and enantiomeric recognition for ammonium salts. Tetrahedron, 2014, 70, 9545–9553. 

54. Ri-Zhen Huang, Gui-Bin Liang, Mei-Shan Li, Yi-Lin Fang, Shi-Feng Zhao, Mei-Mei Zhou, Zhi-Xin Liao*, Jing Sun* and Heng-Shan Wang*. Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-κB activation and cell migration. Med. Chem. Commun., 2019, 10: 584-597.

天然药物化学方向

55.  Cai-Wen Fan, Juan Tang , Jing-Chen Jiang , Mei-Mei Zhou , Mei-Shan Li*, Heng-Shan Wang*, Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and in vivo. Phytomedicine, 2022. 102: 154192.

56. Xi-Lin Ouyang, Feng Qin, Ri-Zhen Huang, Dong Liang, Chun-Gu Wang, Heng-Shan Wang*, Zhi-Xin Liao*. NF-κB inhibitory and cytotoxic activities of hexacyclic triterpene acid constituents from Glechoma longituba. Phytomedicine, 2019, 63, 153037

57. Ri-Zhen Huang, Xiao-Chao Huang, Bin Zhang, Hai-Yang Jia, Zhi-Xin Liao*, Heng-Shan Wang*. 16-O-caffeoyl-16-hydroxylhexadecanoic acid, a medicinal plant-derived phenylpropanoid, induces apoptosis in human hepatocarcinoma cells through ROS-dependent endoplasmic reticulum stress. Phytomedicine, 2018, 41, 33-44.

58. Bin Zhang, Rizhen Huang, Jing Hua, Hong Liang, Yingming Pan, Lumei Dai, Dong Liang, Hengshan Wang*. Antitumor lignanamides from the aerial parts of Corydalis saxicola. Phytomedicine, 2016, 23(13), 1599-1609.

59. Cai Yi Wang, Feng Qin, Chun-Gu Wang, Donghwa Kim, Jin-Jun Li, Xian-Lan Chen, Heng-Shan Wang*, Lee SK*. Novel lignans from Zanthoxylum nitidum and antiproliferation activity of sesaminone in osimertinib-resistant non-small cell lung cancer cells. Bioorg Chem., 2023, 134: 106445.

60. Wei Jiang, Ri-Zhen Huang, Jing Zhang, Tong Guo, Meng-Ting Zhang, Xiao-Chao Huang, Bin Zhang, Zhi-Xin Liao*, Jing Sun*, Heng-Shan Wang*. Discovery of antitumor ursolic acid long-chain diamine derivatives as potent inhibitors of NF-κB. Bioorg. Chem., 2018, 79, 265-276.

61. Fanfan Wang, Ming Li, Cong Lin, Sha Jin, Hongyuan Li, Yuyuan Lu, Hengshan Wang*, Hongshuang Wang*, Xiaohui Wang*. Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity. Bioorg. Med. Chem., 2021, 39: 116131-116131.

62. Feng Qin, Cai Yi Wang, Chun-Gu Wang, Yao Chen, Jin-Jun Li, Mei-Shan Li, Yan-Kui Zhu, Sang Kook Lee*, Heng-Shan Wang*. Undescribed isoquinolines from Zanthoxylum nitidum and their antiproliferative effects against human cancer cell lines. Phytochemistry, 2023, 205: 113476.

63. Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Heng-Shan Wang*, Dong Liang*, Cytotoxic Triterpenoid Saponins from Lysimachia foenum-graecum. Phytochemistry, 2017, 136 , 165-174.

64. Feng Qin, Li Luo, Yao Chen, Gang Wei, Chun-Ce Wei, Xiao-Hua Yang, Yi-Lin Fang, Heng-Shan Wang*. A new phenylpropanoic acid congener from Zanthoxylum nitidum. Nat. Prod. Res., 2023, 9: 1-7.

65. Xi-Lin Ouyang, Tian-Hua Ma, Gui-Liang Xie, Shan Chen, Heng-Shan Wang*, Qiang Jia, En-De Zhang, and Jing-Hua Huang. Acetylated rhamnose triterpenoid saponins from Glechoma longituba analyzed by LC-Q-TOFMS. Chem. Biodivers., 2021, 18: e2100272.

66. Feng Qin, Mei-Shan Li, Jin-Jun Li, Yue Wang, Ke Wang, Jian-Yu Zhou, Dong Liang*, Heng-Shan Wang*. Four New Sesquiterpenoids from Zanthoxylum nitidum. Chem. Biodivers., 2022, 19: e202200449.

67. Wei-Na Yao, Ri-Zhen Huang, Jing Hua, Bin Zhang, Chun-Gu Wang, Dong Liang,,* and Heng-Shan Wang,* Selagintamarlin A, A 1H-2-Benzopyran Selaginellin Analogue Possessing an Unprecedented Skeleton from Selaginella tamariscina. ACS Omega, 2017, 2 (5): 2178–2183.

68. Feng Qin, Lumei Dai, Bin Zhang, Rizhen Huang, Fanfan Wang, Jiangke Qin, Dong Liang*, Hengshan Wang*. (±)-Corysaxicolaine A: a pair of antitumor enantiomeric alkaloid dimers from Corydalis saxicola. Org. Biomol. Chem., 2022, 20: 1396-1400.

69. Ying-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang*, Ying-ming Pan*. Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-beta-enaminonitriles. Org. Biomol. Chem., 2015, 13, 513−519.

70. Feng Qin, Chun-Gu Wang, Mei-Shan Li, Jin-Jun Li, Gang Wei, Na Liao, Heng-Shan Wang*. Structurally diverse isobutylamides from Zanthoxylum nitidum. Fitoterapia. 2023, 164: 105381.

71. Jia-Zi Luo, Mei-Shan Li, Xi-Xi Song, Yi-Lin Fang, Hai-Ning Mo, Jing-Chen Jiang, Hai-Yan Zhao, Heng-Shan Wang*. New alkaloids and their in vitro antitumor activity of Corydalis balansae. Fitoterapia. 2022, 162: 105289.

72. Feng Qin, Fan-Fan Wang, Chun-Gu Wang, Yao Chen, Mei-Shan Li, Yan-Kui Zhu, Xiao-chao Huang, Cai-Wen Fan*, Heng-Shan Wang*. The neurotrophic and antineuroinflammatory effects of phenylpropanoids from Zanthoxylum nitidum var. tomentosum (Rutaceae). Fitoterapia, 2021, 153: 104990.

73. Xi-Lin Ouyang, Wen-Hua Mao, Chun-Gu Wang, Ying-Ming Pan, Dong Liang*, Heng-Shan Wang*. Five new 11α, 12α-epoxy pentacyclic triterpenoid saponins with anticoagulant activities from Glechoma longituba. Fitoterapia, 2019, 138: 104345

74. Yuan Zhu, Ri-Zhen Huang, Chun-Gu Wang, Xi-Lin Ouyang, Xiao-Teng Jing, Dong Liang*, and Heng-Shan Wang*.New inhibitors of matrix metalloproteinases 9 (MMP-9): lignans from Selaginella moellndorffii. Fitoterapia, 2018,130: 281–289

75. Ri-Zhen Huang, Le Jin, Chun-Gu Wang, Xiao-Jing Xu, Ying Du, Na Liao, Min Ji, Zhi-Xin Liao*, Heng-Shan Wang*. A pentacyclic triterpene derivative possessing polyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygen species-dependent NF-κB pathway. Eur. J. Pharmacol.. 2018, 838: 157-169.

76. Chun-Gu Wang, Wei-Na Yao, Bin Zhang, Jing Hua, Dong Liang*, Heng-Shan Wang*. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. Bioorg. Med. Chem. Lett., 2018, 28, 2413-2417.

77. Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*, Three new triterpenoid saponins from the aerial parts of Lysimachia foenumgraecum.  Phytochemistry Letters, 2017, 22, 133-137. 

78. Cai Yi Wang, Ji Sun Lee, Xiang Dong Su, Hong Xu Li, Sang Kook Lee, Heng-Shan Wang* Young Ho Kim* and Seo Young Yang*. Three new constituents from the aerial parts of Tetrastigma hemsleyanum and their cytotixic and soluble epoxide hydrolase inhibitory activities. Phytchem. Lett., 2018, 27: 25-29.

79. Ri-Zhen Huang, Bin Zhang, Xiao-Chao Huang, Gui-Bin Liang, Jian-Mei Qin, Ying-Ming Pan, Zhi-Xin Liao*, Heng-Shan Wang*. Synthesis and biological evaluation of terminal functionalized thiourea-containing dipeptides as antitumor agents. RSC Advances, 2017, 7(15), 8866-8878

80. Qiang Wu, Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. Cu (otf) 2-catalyzed three-component annulation reaction: One-pot synthesis of 4, 5-dihydropyrazole from aldehydes, hydrazines and alkenes. RSC Advances. 2012, 2: 10167–10170.

81. Ri-Zhen Huang, Cai-Yi Wang, Jian-Fei Li, Gui-Yang Yao, Ying-Ming Pan, Man-Yi Ye, Heng-Shan Wang*, Ye Zhang*. Synthesis, antiproliferative and apoptosis-inducing effects of novel asiatic acid derivatives containing α-aminophosphonates. RSC Advances., 2016, 6: 62890–62906.

82. Yan He, Yu-yang Xie, Ying-chun Wang, Xiao-min Bin, Da-chao Hu, Heng-shan Wang*, Ying-ming Pan*. TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN. RSC Advances, 2016, 6(64), 58988-58993.

83. Na Liao, Mei-Shan Li, Feng Qin*, Jing-Chen Jiang, Ri-Da Luo, Xian-Lan Chen, Mei-Mei, Zhou, Yan-Kui Zhu, Heng-Shan Wang*. A new phenolic acid from Zanthoxylum nitidum var. tomentosum (Rutaceae) and its chemotaxonomic significance. Biochem. Syst. Ecol., 2021, 99, 104351.

84. Gui-yang Yao, Man-yi Ye, Ri-zhen Huang, Ya-jun Li, Yong-tao Zhu, Ying-ming Pan, Zhi-Xin Liao*, Heng-shan Wang*. Synthesis and antitumor activity evaluation of maleopimaric acid N-aryl imide atropisomers. Bioorg. Med. Chem. Lett., 2013, 23, 6755-6758

85. Gui-Yang Yao, Man-Yi Ye, Ri-Zhen Huang, Ya-Jun Li, Ying-Ming Pan, Qing Xu, Zhi-Xin Liao*, Heng-Shan Wang*. Synthesis and antitumor activities of novel rhein α-aminophosphonates conjugates. Bioorg. Med. Chem. Lett., 2014, 24, 501–507

86. Xiao-Chao Huang, Meng Wang, Heng-Shan Wang, Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan*. Synthesis and antitumor activities of novel dipeptide derivativesderived from dehydroabietic acid. Bioorg. Med. Chem. Lett., 2014, 24, 1511–1518. 

87. Xiao-Chao Huang, Meng Wang, Ying-ming Pan, Xiao-Yan Tian, Heng-shan Wang*, Ye Zhang*. Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives. Bioorg. Med. Chem. Lett., 2013, 23(19), 5283–5289.

88. Pan, Yingming*; He, Chunhuan; Wang, Hengshan*; Ji, Xiaowen; Wang, Kai; Liu, Peizhen Antioxidant activity of microwave-assisted extract of Buddleia officinalis and its major active component. Food Chemistry, 2010, 121, 15, 497–502.

89. Yingming Pan,*, Zhiren Zhu, Zhili Huang, Hengshan Wang*, Ying Liang, Kai Wang, Qian Lei, Min Liang. Characterisation and free radical scavenging activities of novel red pigment from Osmanthus fragrans’ seeds. Food Chemistry, 2009, 112: 909–913.

90. Yingming Pan*, Kai Wang, Siqin Huang, Hengshan Wang*, Xiaomei Mu, Chunhuan He, Xiaowen Ji, Jie Zhang and Fujuan Huang. Antioxidant activity of microwave- assisted extract of longan (Dimocarpus Longan Lour.) peel. Food Chemistry, 2008, 106(3): 1264-1270.

91. Yingming Pan*, Jinchan Zhu, Hengshan Wang*, Xiaopu Zhang, Ye Zhang, Chunhuan He, Xiaowen Ji, Haiyun Li. Antioxidant activity of ethanolic extract of Cortex fraxini and use in peanut oil. Food Chemistry, 2007, 103: 913–918.

92.  Yingming Pan*, Xiaopu Zhang, Hengshan Wang*, Ying Liang, Jinchan Zhu, Haiyun Li, Zhi Zhang, Qingmao Wu. Antioxidant potential of ethanolic extract of Polygonum cuspidatum and application in peanut oil. Food Chemistry, 2007, 105 (4):1518-1524.

93.  Heng-Shan Wang*, Dian-Hua Gan, Xiao-Pu Zhang, Ying-Ming Pan. Antioxidant capacity of the extracts from pulp of Osmanthus fragrans and its components. LWT - Food Sci. Technol. 2010, 43, 319–325.

94.  Ming-Xiong Tan, Dian-hua Gan, Liu-xin Wei, Ying-ming Pan, Shao-qing Tang, Heng-shan Wang*. Isolation and characterization of pigment from Cinnamomum burmannii’peel. Food Res. Int. 2011, 44: 2289–2294. 

95.  Qi-Ming Pan, Yu-Huan Li, Jing Hua, Fu-Ping Huang, Heng-Shan Wang, Dong Liang*. Antiviral Matrine-type Alkaloids from the Rhizomes of Sophora tonkinensis. J. Nat. Prod., 2015, 78(7), 1683-1688.

96. Le Jin, Hong-En Qu, Xiao-Chao Huang, Ying-Ming Pan, Dong Liang, Zhen-Feng Chen, Heng-Shan Wang,* and Ye Zhang*. Synthesis and Biological Evaluation of Novel Dehydroabietic Acid Derivatives Conjugated with Acyl-Thiourea Peptide Moiety as Antitumor Agents, Int. J. Mol. Sci. 2015, 16, 14571-14593.

97.  Man-Yi Ye, Gui-Yang Yao, Jing-Chen Wei, Ying-Ming Pan*, Zhi-Xin Liao, Heng-Shan Wang*. Synthesis, cytotoxicity, DNA binding and apoptosis of rhein phosphonate derivatives as antitumor agents. Int. J. Mol. Sci., 2013, 14, 9424–9439.

98.  Guiyang Yao, Manyi Ye, Yongtao Zhu, Zhixin Liao*, Hengshan Wang*. Synthesis and pharmacological evaluation of maleopimaric N-arylimides: Identification of novel proapoptotic agents, Anti-Cancer Agent. Med. Chem., 2016, 16(6), 755-762.  

99. Huang, R. Z., Hua, S. X., Wang, C. Y., Pan, Y. M., Qin, J. M., Ding, Z. Y., Zhang, Y*. & Wang, H. S*. 4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies. Anti-Cancer Agent. Med. Chem., 2017, 17(4), 576-589.

100.  Pingtan Lin, Shulin Zhao*, Xin Lu, Fanggui Ye, Hengshan Wang*. Preparation of a dual- enzyme co-immobilized capillary microreactor and simultaneous screening of multiple enzyme inhibitors by capillary electrophoresis, J. Sep. Sci., 2013, 36(15): 2538–2543.

101.  Ying-Chun Wang, Chun-Hua Su, Fang-Yao Li, Lu-Zhi Liu, Ying-Ming Pan, Xiu-Rong Wu, Heng-Shan Wang*. Syntheses, characterization and fluorescent properties of two series of dehydroabietic acid C-ring derivatives. Spectrochim. Acta A, 2010, 76, 328–335.

102.  Xi-Lin Ouyang, L-X Wei , Heng-Shan Wang*, Ying-Ming Pan*. Antioxidant activity and phytochemical composition of Osmanthus fragrans' pulps. S. Afr. J. Bot., 2015, 98: 162–166.

103.  XL Ouyang, XM Fang, YM Pan, LX Wei, HS Wang*, Development of HPLC Fingerprint for the Quality Control of Euonymus fortunei and Distinguishing from Related Species. Acta Chromatogr., 2012, 24(2): 301-316.

104.  Rui-Yun Yang, Xi-Lin Ouyang, Dian-Hua Gan, Heng-Shan Wang*, Yi-Zheng Li, Ying-Ming Pan*. Isolation and Determination of Iridoid Glycosides From the Seeds of Osmanthus fragrans by HPLC. Anal. Lett., 2012, 46: 745–752.

105.  Xi-Lin Ouyang,, Liu-Xin Wei, Xian-Ming Fang, Heng-Shan Wang*, Ying-Ming Pan*. Flavonoid constituents of Euonymus fortune. Chem. Nat. Compd., 2013, 49(3), 428–431.

106. Yi-Zheng Li, Ying-Ming Pan, Xiao-Yan Huang, Heng-Shan Wang*. Withanolides from Physalis alkekengi var. francheti. Helv. Chim. Acta. 2008, 91: 2284－2291.

107.  Hengshan Wang, Shulin Zhao*, Min He, Zhicai Zhao, Yingming Pan, Qian Liang. Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acids derivatives by capillary micellar electrokinetic chromatography. J. Sep. Sci., 2007, 30: 2748-2753.

108.  Hengshan.Wang, Rongcan Zhang, Shulin Zhao*, Lidong Tang and Yingming Pan. Synthesis and application of dehydroabietylisothiocyante as a new chiralderivatizing agent for the enantiomeric separation of chiral compounds by capillary electrophoretic. Anal. Chim. Acta 2006, 560: 64–68.

109.  Shulin Zhao*, Rongcan Zhang, Hengshan Wang*, Lidong Tang and Yingming Pan. Capillary electrophoresis enantioselective separation of vigabatrin enantiomers by precolumn derivatization. J. Chromatogr. B, 2006, 833 : 186–190.

---发明专利---

1．王恒山; 潘英明; 黎霜. 从罗汉果残渣中提取多种成分，ZL 02133627.X，2004，中国专利授权

2．王恒山; 童碧海; 潘英明. 松香基吖啶类化合物的合成、其制造方法及其用途， ZL 200410040714.1，2006，中国专利授权

3．王恒山; 张业; 潘英明.  脱氢松香酸甲酯呋咱衍生物，其合成方法及其用途，申请号：200410081396.3，2004，中国专利

4. 王恒山, 戴伟龙, 潘英明, 姚贵阳, 程克光, 陈振锋, 田小艳. 茜素二氧杂环己烷衍生物及其制备方法和应用. 专利号: 201210324944.5.

5. 王恒山; 潘英明; 黄卫根; 谭恒; 刘志芳; 刘陆智. 脱氢松香基硫脲衍生物及其制备方法和应用 专利号:201010284217

6. 王恒山，黄日镇，潘英明，姚贵阳，戴伟龙，叶鳗仪，陈振锋. 大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号:201310475681.2

7. 王恒山, 黄日镇, 潘英明, 姚贵阳, 戴伟龙, 叶鳗仪, 陈振锋. 双乙酰大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号201310475685.0

8. 王恒山, 潘英明, 姚贵阳, 叶鳗仪, 黄日镇. 茜素氨基膦酸酯衍生物及其合成方法和应用. 专利号ZL201310730928.0

9. 王恒山，梁东，姚维娜，黄日镇，王春姑，潘英明，张斌，代禄梅。一种含吡喃环酚类化合物及其制备方法和应用，专利申请号201710053753.2

---联系方式---

Email：hshwang2002@126.com；QQ 1355841101

电话,传真：0773-2120958